Клинические вариации увеитов при иммуновоспалительных заболеваниях. Обзор литературы. Часть 2

В предыдущей части обзора обсуждались актуальные клинические и диагностические аспекты некоторых неинфекционных увеитов у больных с иммуновоспалительными заболеваниями. В этой части будет продолжено обсуждение современного состояния вопроса в отношении глазных манифестаций ряда других иммуновоспалительных состояний. Помимо увеитов, ассоциированных со спондилоартропатиями, ревматоидным артритом, болезнью Стилла, ювенильным идиопатическим артритом и системным саркоидозом, описанных в предыдущей части, нередки также глазные проявления при системных васкулитах, системной красной волчанке, синдроме Фогта — Коянаги — Харада. Несмотря на разработанные многочисленные схемы диагностики и алгоритмы терапии, многое в патогенезе увеитов, связанных с иммуновоспалительными заболеваниями, остается неизученным. Не теряет актуальность необходимость разработки персонализированных и мультидисциплинарных подходов для лечения и диагностики неинфекционных увеитов при многочисленных системных иммуновоспалительных заболеваниях. Углубленное понимание механизмов этиопатогенеза иммуновоспалительных процессов позволит определить новые подходы в лечении пациентов с увеитами.

1. Cаlamia K.T., Wilson F.C., Icen M., Crowson C.S., Gabriel S.E., Kremers H.M. Epidemiology and clinical characteristics of Beçcet’s disease in the US: a population based study. Arthritis Rheum. 2009;61(5):600–604. DOI: 10.1002/art.24423

2. McCannel C.A., Holland G.N., Helm C.J., Cornell P.J., Winston J.V., Rimmer T.G., UCLA Community Based Uveitis Study Group. Causes of uveitis in the general practice of ophthalmology. Am J Ophthalmol. 1996 Jan;121(1):35–46. DOI: 10.1016/s0002 9394(14)70532 x

3. Jakob E., Reuland M.S., Mackensen F., Harsch N., Fleckenstein M. Lorenz H.M., Max R., Becker M.D. Uveitis subtypes in a german interdisciplinary uveitis center analysis of 1916 patients. J Rheumatol. 2009 Jan;36(1):127–136. DOI: 10.3899/jrheum.080102

4. Chora I., Borges T., Dias C., Ourique C., Vilaça J., Ferreire S., Vaz Marques P., Silva S., Dias C. Clinical Management of Uveitis in Systemic Rheumatic Autoimmune Diseases in Adults. Autoimmun Infec Dis. 2015;1 (1): DOI: 10.16966/2470 1025.104

5. Конькова А.Ю., Гаврилова Т.В., Черешнева М.В. Состояние заболеваемости увеитами в Пермском крае. Вестник Совета молодых ученых и специалистов Челябинской области. 2015;2(4(11)):31–35.

6. Кузнецова Т.И., Астахов Ю.С. Можно ли сократить долю увеитов неясной этиологии? Офтальмологические ведомости. 2019;12(3):21–30. DOI: 10.17816/OV16369

7. Tran V.T., Auer C., Guex Crosier Y., Pittet N., Herbort Carl P. Epidemiology of uveitis in Switzerland. Ocul Immunol Inflamm. 1994;2(3):169–176. DOI: 10.3109/09273949409057073

8. Hamdan A., Mansour W., Uthman I., Masri A.F., Nasr F., Arayssi T. Behçet’s disease in Lebanon: clinical profile, severity and two decade comparison. Clin Rheumatol. 2006 May;25(3):364–367. DOI: 10.1007/s10067 005 0058 4

9. Mousa A.R., Marafie A.A., Rifai K.M., Dajani A.I., Mukhtar M.M. Behçet’s disease in Kuwait, Arabia. A report of 29 cases and a review. Scand J Rheumatol. 1986;15(3):310–332. DOI: 10.3109/03009748609092599

10. Fabiani C., Vitale A., Orlando I., Sota J., Capozzoli M., Franceschini R., Galeazzi M., Tosi G.M., Frediani B., Cantarini L. Quality of life impairment in Behçet’s disease and relationship with disease activity: a prospective study. Internal and Emergency Medicine. 2017;12(7):947–955. DOI: 10.1007/s11739 017 1691 z

11. Kaçmaz R.O., Kempen J.H., Newcomb C., Gangaputra S., Daniel E., Jabs D.A., Foster S.C. Ocular inflammation in Behçet disease: incidence of ocular complications and of loss of visual acuity. Am J Ophthalmol. 2008 Dec;146(6):828–836. DOI: 10.1016/j.ajo.2008.06.019

12. Verity D.H., Wallace G.R., Vaughan R.W., Stanford M.R. Behçet’s disease: from Hippocrates to the third millennium. Br J Ophthalmol. 2003 Sep;87(9):1175–1183. DOI: 10.1136/bjo.87.9.1175

13. Taylor S.R., Singh J., Menezo V., Wakefield D., McCluskey P., Lightman S. Behçet disease: visual prognosis and factors influencing the development of visual loss. Am J Ophthalmol. 2011 Dec;152(6):1059–1066. DOI: 10.1016/j.ajo.2011.05.032

14. Desbois A.C., Terrada C., Cacoub P., Bodaghi B., Saadoun D. Les manifestations oculaires de la maladie de Behçet [Ocular manifestations in Behçet’s disease]. Rev Med Interne. 2018 Sep;39(9):738–745. French. DOI: 10.1016/j.revmed.2018.02.022

15. Abd El Latif E., Abdel Kader Fouly Galal M., Tawfik M.A., Elmoddather M., Nooreldin A., Shamselden Yousef H. Pattern of Uveitis Associated with Behçet’s Disease in an Egyptian Cohort. Clin Ophthalmol. 2020;14:4005–4014. Published 2020 Nov 20. DOI: 10.2147/OPTH.S287298

16. Khairallah M., Accorinti M., Muccioli C., Kahloun R., Kempen J.H. Epidemiology of Behçet disease. Ocul Immunol Inflamm. 2012 Oct;20(5):324–335. DOI: 10.3109/09273948.2012.723112

17. Davatchi F., Shahram F., Chams Davatchi C., Shams H., Abdolahi B.S., Nadji A., Faezi T., Akhlaghi M., Ghodsi Z., Karimi N., Kavosi H., Mohtasham N., Masoumi M., Shadmanfar S., Mousavi M. Behcet’s disease in Iran: Analysis of 7641 cases. Mod Rheumatol. 2019 Nov;29(6):1023–1030. DOI: 10.1080/14397595.2018.1558752

18. Tugal Tutkun I., Onal S., Yaycioglu A.R., Altunbas H.H., Urgancioglu M. Uveitis in Behçet disease: an analysis of 880 patients. Am J Ophthalmol. 2004;138(3):373–380. DOI: 10.1016/j.ajo.2004.03.022

19. Yang P., Fang W., Meng Q., Ren Y., Xing L., Kijlstra A. Clinical features of Chinese patients with Behçet’s disease. Ophthalmology. 2008 Feb;115(2):312–318.e4. DOI: 10.1016/j.ophtha.2007.04.056

20. Namba K., Goto H., Kaburaki T., Kitaichi N., Mizuki N., Asukata Y., Fujino Y., Meguro A., Sakamoto S., Shibuya E., Yokoi K., Ohno S. A Major Review: Current Aspects of Ocular Behçet’s Disease in Japan. Ocul Immunol Inflamm. 2015;23 Suppl 1:S1–23. DOI: 10.3109/09273948.2014.981547

21. Foster C.S., Vitale A.T. Diagnosis and Treatment of Uveitis. 2nd Edition. New Delhi: Jaypee Brothers Medical Publishers; 2013. P. 863–864.

22. Hayashi T., Mizuki N. Ocular Manifestations in Behçet’s Disease. JMAJ. 2006:49(7–8):260–268.

23. Onal S., Tugal Tutkun I. Behçet Disease. In: Biswas J., Majumder P.D. (eds). Uveitis: An Update. India: Springer. 2016. P. 17–31.

24. Sota J., Cantarini L., Vitale A. Long Term Outcomes of Behçet’s Syndrome Related Uveitis: A Monocentric Italian Experience May 2020 Mediators of Inflammation 2020;8:1–8. DOI: 10.1155/2020/6872402

25. Çakar Özdal P. Behçet’s Uveitis: Current Diagnostic and Therapeutic Approach. Turk J Ophthalmol. 2020 Jun 27;50(3):169–182. DOI: 10.4274/tjo.galenos.2019.60308

26. Pathanapitoon K., Kunavisarut P., Saravuttikul F. A., Rothova A. Ocular manifestations and visual outcomes of Behçet’s uveitis in a Thai population. Ocular Immunologyand Inflammation. 2019:27(1):2–6. DOI: 10.1080/09273948.2017.1351570

27. Wakefield D., Cunningham E.T., Tugal Tutkun I., Khairallah M., Ohno S., Zierhut M. Controversies in Behçet disease. Ocul Immunol Inflamm. 2012;20(1):6–11. DOI: 10.3109/09273948.2011.649153

28. Ozdal P.C., Ortaç S., Taşkintuna I., Firat E. Posterior segment involvement in ocular Behçet’s disease. Eur J Ophthalmol. 2002 Sep Oct;12(5):424–431. DOI: 10.1177/112067210201200514

29. Sachdev N., Kapali N., Singh R., Gupta V., Gupta A. Spectrum of Behçet’s disease in the Indian population. Int Ophthalmol. 2009;29(6):495–501. DOI: 10.1007/s10792 008 9273 8

30. Tugal Tutkun I. Behçet’s Uveitis. Middle East Afr J Ophthalmol. 2009;16:219–224. DOI: 10.4103/0974-9233.58425

31. Rosenbaum J.T., Sibley C.H., Lin P. Retinal vasculitis. Curr Opin Rheumatol. 2016 May;28(3):228–235. DOI: 10.1097/BOR.0000000000000271

32. Pantanelli S.M., Khalifa Y.M. Retinal manifestations of autoimmune and inflammatory disease. Int Ophthalmol Clin. 2012 Winter;52(1):25–46. DOI: 10.1097/IIO.0b013e31823bbbe9

33. Stübiger N., Zierhut M., Kötter I. Ocular manifestations in Behçet’s disease. In: Zierhut M, Ohno S, editors. Immunology of Behçet’s Disease. Lisse, Netherlands: Swets & Zeitlinger; 2003. P. 36–45.

34. Kahloun R., Ben Yahia S., Mbarek S., Attia S., Zaouali S., Khairallah M. Macular involvement in patients with Behçet’s uveitis. J Ophthalmic Inflamm Infect. 2012;2(3):121–124. DOI: 10.1007/s12348-012-0075-9

35. Krause L., Köhler A.K., Altenburg A., Papoutsis N., Zouboulis C.C., Pleyer U., Stroux A., Foerster M.H. Ocular involvement in Adamantiades Behçet’s disease in Berlin, Germany. Graefes Arch Clin Exp Ophthalmol. 2009 May;247(5):661–666. DOI: 10.1007/s00417-008-0983-4

36. Kidd D.P. Optic neuropathy in Behçet’s syndrome. J Neurol. 2013 Dec;260(12):3065–3070. DOI: 10.1007/s00415 013 7070 4

37. Khanfir M.S., Belfeki N., Said F., Ben Salem T., Ben Ghorbel I., Lamloum M., Hamzaoui A., Houman M.H. Inflammatory optic neuropathy in Behçet’s disease. Reumatismo. 2015 Dec 23;67(4):156–160. DOI: 10.4081/reumatismo.2015.835

38. Siva A., Kantarci O.H., Saip S., Altintas A., Hamuryudan V., Islak C., Koçer N., Yazici H. Behçet’s disease: diagnostic and prognostic aspects of neurological involvement. J Neurol. 2001 Feb;248(2):95–103. DOI: 10.1007/s004150170242

39. Kaçmaz R.O., Kempen J.H., Newcomb C., Gangaputra S., Daniel E., Levy Clarke G.A., Nussenblatt R.B., Rosenbaum J.T., Suhler E.B., Thorne J.E., Jabs D.A., Foster C.S.; Systemic Immunosuppressive Therapy for Eye Diseases Cohort Study Group. Ocular inflammation in Behçet disease: incidence of ocular complications and of loss of visual acuity. Am J Ophthalmol. 2008 Dec;146(6):828–836. DOI: 10.1016/j.ajo.2008.06.019

40. Zink J.M., Singh Parikshak R., Johnson C.S., Zacks D.N. Hypopyon uveitis associated with systemic lupus erythematosus and antiphospholipid antibody syndrome. Graefes Arch Clin Exp Ophthalmol. 2005 Apr;243(4):386–388. DOI: 10.1007/s00417-004-1022-8

41. Albert D.M., Miller J., Azar D., Young L.H. Albert and Jakobiec’s Principles and Practice of Ophthalmology. 1994. WB Saunders: Philadelphia, 2894–2901.

42. Yacoub Wasef S.Z. Gender differences in systemic lupus erythematosus. Gend Med. 2004 Aug;1(1):12–17. DOI: 10.1016/s1550 8579(04)80006 8

43. Ushiyama O., Ushiyama K., Koarada S., Tada Y., Suzuki N., Ohta A., Oono S., Nagasawa K. Retinal disease in patients with systemic lupus erythematosus. Ann Rheum Dis. 2000 Sep;59(9):705–708. DOI: 10.1136/ard.59.9.705

44. Bishko F. Retinopathy in systemic lupus erythematosus. A case report and review of the literature. Arthritis Rheum. 1972 Jan Feb;15(1):57–63. DOI: 10.1002/art.1780150109

45. Durukan A.H., Akar Y., Bayraktar M.Z., Dinc A., Sahin O.F. Combined retinal artery and vein occlusion in a patient with systemic lupus erythematosus and antiphospholipid syndrome. Can J Ophthalmol. 2005 Feb;40(1):87–89. DOI: 10.1016/s0008-4182(05)80126-7

46. Baglio V., Gharbiya M., Balacco Gabrieli C., Mascaro T., Gangemi C., Di Franco M., Pistolesi V., Morabito S., Pecci G., Pierucci A. Choroidopathy in patients with systemic lupus erythematosus with or without nephropathy. J Nephrol. 2011 Jul Aug;24(4):522–529. DOI: 10.5301/JN.2011.6244

47. Feinglass E.J., Arnett F.C., Dorsch C.A., Zizic T.M., Stevens M.B. Neuropsychiatric manifestations of systemic lupus erythematosus: diagnosis, clinical spectrum, and relationship to other features of the disease. Medicine (Baltimore). 1976 Jul;55(4):323–339. DOI: 10.1097/00005792 197607000 00004

48. Cunningham E.T. Jr., Alfred P.R., Irvine A.R. Central serous chorioretinopathy in patients with systemic lupus erythematosus. Ophthalmology. 1996 Dec;103(12):2081–2090. DOI: 10.1016/s0161 6420(96)30385 0

49. Nguyen Q.D., Uy H.S., Akpek E.K., Harper S.L., Zacks D.N., Foster C.S. Choroidopathy of systemic lupus erythematosus. Lupus. 2000;9(4):288–298. DOI: 10.1191/096120300680199024

50. Sivaraj R.R., Durrani O.M., Denniston A.K., Murray P.I., Gordon C. Ocular manifestations of systemic lupus erythematosus. Rheumatology (Oxford). 2007 Dec;46(12):1757–1762. DOI: 10.1093/rheumatology/kem173

51. Karim S., Majithia V. Devic’s syndrome as initial presentation of systemic lupus erythematosus. Am J Med Sci. 2009 Sep;338(3):245–247. DOI: 10.1097/MAJ.0b013e3181a8be1d

52. Jacobi C., Stingele K., Kretz R., Hartmann M., Storch Hagenlocher B., Breitbart A., Wildemann B. Neuromyelitis optica (Devic’s syndrome) as first manifestation of systemic lupus erythematosus. Lupus. 2006;15(2):107–109. DOI: 10.1191/0961203306lu2265cr

53. Adawi M., Bisharat B., Bowirrat A. Systemic Lupus Erythematosus (SLE) Complicated by Neuromyelitis Optica (NMO — Devic’s Disease): Clinic Pathological Report and Review of the Literature. Clin Med Insights Case Rep. 2014 Jun 2;7:41–47. DOI: 10.4137/CCRep.S15177

54. Jensen J.L., Bergem H.O., Gilboe I.M., Husby G., Axéll T. Oral and ocular sicca symptoms and findings are prevalent in systemic lupus erythematosus. Journal of Oral Pathology and Medicine. 1999:28(7)317–322. DOI: 10.1111/j.1600 0714.1999.tb02047.x

55. Sitaula R., Shah D.N., Singh D. The spectrum of ocular involvement in systemic lupus erythematosus in a tertiary eye care center in Nepal. Ocul Immunol Inflamm. 2011 Dec;19(6):422–425. DOI: 10.3109/09273948.2011.610023

56. Palejwala N.V., Walia H.S., Yeh S. Ocular manifestations of systemic lupus erythematosus: a review of the literature. Autoimmune Dis. 2012;2012:290898. DOI: 10.1155/2012/290898

57. Silpa archa S., Lee J.J., Foster C.S. Ocular manifestations in systemic lupus erythematosus. Br J Ophthalmol. 2016 Jan;100(1):135–141. DOI: 10.1136/bjophthal mol 2015 306629

58. Dollfus H., Häfner R., Hofmann H.M., Russo R.A., Denda L., Gonzales L.D., De-Cunto C., Premoli J., Melo Gomez J., Jorge J.P., Vesely R., Stubna M., Dufier J.L., Prieur A.M. Chronic infantile neurological cutaneous and articular/neonatal onset multisystem inflammatory disease syndrome: ocular manifestations in a recently recognized chronic inflammatory disease of childhood. Arch Ophthalmol. 2000 Oct;118(10):1386–1392. DOI: 10.1001/archopht.118.10.1386

59. Abad S., Wieërs G., Colau D., Wildmann C., Delair E. Absence of recognition of common melanocytic antigens by T cells isolated from the cerebrospinal fluid of a Vogt Koyanagi Harada patient. Mol Vis. 2014 Jul 2;20:956–969. PMID: 24991188; PMCID: PMC4077848

60. Liu B., Deng T., Zhu L., Zhong J. Association of human leukocyte antigen (HLA) DQ and HLA DQA1/DQB1 alleles with Vogt Koyanagi Harada disease: A systematic review and meta analysis. Medicine (Baltimore). 2018 Feb;97(7):e9914. DOI: 10.1097/MD.0000000000009914

61. Rao N.A., Sukavatcharin S., Tsai J.H. Vogt Koyanagi Harada disease diagnostic criteria. Int Ophthalmol. 2007 Apr Jun;27(2 3):195–199. DOI: 10.1007/s10792 006 9021 x

62. Mota L.A., Santos A.B. Vogt Koyanagi Harada’s syndrome and its multisystem involvement. Rev Assoc Med Bras (1992). 2010 Sep Oct;56(5):590–595. English, Portuguese. DOI: 10.1590/s0104 42302010000500023

63. Balci O., Gasc A., Jeannin B., Herbort C.P. Jr. Enhanced depth imaging is less suited than indocyanine green angiography for close monitoring of primary stromal choroiditis: a pilot report. Int Ophthalmol. 2017 Jun;37(3):737–748. DOI: 10.1007/s10792-016-0303-7

64. Lodhi S.A., Reddy J.L., Peram V. Clinical spectrum and management options in Vogt Koyanagi Harada disease. Clin Ophthalmol. 2017 Aug 7;11:1399–1406. DOI: 10.2147/OPTH.S134977

65. Attia S., Khochtali S., Kahloun R., Zaouali S., Khairallah M. Vogt–Koyanagi–Harada disease. Expert Review of Ophthalmology. 2012;7:565–585. DOI: 10.1586/eop.12.63

66. Bacsal K., Wen D.S., Chee S.P. Concomitant choroidal inflammation during anterior segment recurrence in Vogt Koyanagi Harada disease. Am J Ophthalmol. 2008 Mar;145(3):480–486. DOI: 10.1016/j.ajo.2007.10.012

67. Takemoto Y., Namba K., Mizuuchi K., Iwata D., Uno T., Ohno S., Hirooka K., Hashimoto Y., Saito W., Sugiyama K., Ishida S. Choroidal circulation impairment during the anterior recurrence of Vogt Koyanagi Harada disease confirmed with indocyanine green angiography and laser speckle flowgraphy. Acta Ophthalmol. 2016 Nov;94(7):e629–e636. DOI: 10.1111/aos.13024

68. Taylor S., Lightman S. Recurrent anterior uveitis in patients with Vogt Koyanagi Harada syndrome. Arch Ophthalmol. 2004 Jun;122(6):922–923. DOI: 10.1001/archopht.122.6.922

69. Tagawa Y., Namba K., Mizuuchi K., Takemoto Y., Iwata D., Uno T., Fukuhara T., Hirooka K., Kitaichi N., Ohno S., Ishida S. Choroidal thickening prior to anterior recurrence in patients with Vogt Koyanagi Harada disease. Br J Ophthalmol. 2016 Apr;100(4):473–477. DOI: 10.1136/bjophthalmol-2014 306439

70. Magliyah M.S., Al Fakhri A.S., Al Dhibi H.A. Proliferative retinopathy as a feature of Vogt Koyanagi Harada Disease: a report of two cases. BMC Ophthalmol. 2020:20:470. DOI: 10.1186/s12886-020-01736-y